This white paper describes destruction efficiency testing run by Carus and Picarro, Inc. on Carus’s CARULITE® 500 catalyst media using Picarro’s Ethylene Oxide (EtO) Cavity Ring-Down Spectrometer (CRDS) technology. Picarro’s technology provides industry-leading sensitive, accurate, and virtually drift free measurements at levels reaching below a part per billion, making it an excellent choice for studies where high levels of destruction efficiency need to be characterized and confirmed. Measurements were run in a lab setting using an EtO standard blended to between 100 and 1000 ppm—concentrations typically seen by Catalytic Oxidizer systems during active batch sterilization. We describe a tracer method using CH₄, H₂O, and CO₂ to confirm flow of the process gas to the analyzer, and we show that CARULITE® 500 handily outperforms even the strictest regulatory standards in both destruction efficiency and effluent concentrations, with average observed destruction efficiency of 99.99988% and average outlet concentrations of 0.2 ppb across inlet concentrations.