Privacy curtain contamination, including with multidrug-resistant organisms, and the associated infection transmission risks have been well described; however, current approaches for addressing these risks and available guidance are limited. The present study describes the successful reduction of curtain contamination in five different units within a tertiary care hospital utilizing continuous dry hydrogen peroxide (DHP™). Microbial load was reduced by 99.47 percent on Day 1 and statistically significant reductions were maintained throughout the 28-day study.